منابع مشابه
Skeletal Muscle Na+ Channel Disorders
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Na(v)1.4. The main symptoms of these disorders are myotonia or periodic paralysis caused by changes in skeletal muscle fiber excitability. Symptoms of these disorders vary from mild or latent disease to incapacitating or even death in severe ca...
متن کاملNa channel distribution in vertebrate skeletal muscle
The loose patch voltage clamp has been used to map Na current density along the length of snake and rat skeletal muscle fibers. Na currents have been recorded from (a) endplate membrane exposed by removal of the nerve terminal, (b) membrane near the endplate, (c) extrajunctional membrane far from both the endplate and the tendon, and (d) membrane near the tendon. Na current densities recorded d...
متن کاملNa Channel Distribution in Vertebrate Skeletal Muscle
The loose patch voltage clamp has been used to map Na current density along the length of snake and rat skeletal muscle fibers . Na currents have been recorded from (a) endplate membrane exposed by removal of the nerve terminal, (b) membrane near the endplate, (c) extrajunctional membrane far from both the endplate and the tendon, and (d) membrane near the tendon . Na current densities recorded...
متن کاملKinetic diversity of Na+ channel bursts in frog skeletal muscle
Individual Na+ channels of dissociated frog skeletal muscle cells at 10 degrees C fail to inactivate in 0.02% of depolarizing pulses, thus producing bursts of openings lasting hundreds of milliseconds. We present here a kinetic analysis of 87 such bursts that were recorded in multi-channel patches at four pulse potentials. We used standard dwell-time histograms as well as fluctuation analysis t...
متن کاملSkeletal Muscle Na + Channels
Voltage-dependent Na + channels are thought to sense membrane potential with fixed charges located within the membrane's electrical field. Measurement of open probability (Po) as a function of membrane potential gives a quantitative indication of the number of such charges that move through the field in opening the channel. We have used single-channel recording to measure skeletal muscle Na § c...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2011
ISSN: 1663-9812
DOI: 10.3389/fphar.2011.00063